Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Radboud University Medical Center13 enrolled

Overview

A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Hypertension

Interventions

atorvastatin 80 mgDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * (Known) hypertension * stable drug therapy for at least 2 months * age 18-70 jaar * BMI 18-35 kg/m2 * Sinusrhythm Exclusion Criteria: * Recent cardiovascular event \<6 mnd * Plasma Creatinin: * female: \>120 mmol/L * male: \>133 mmol/L * use of: * tricyclic antidepressants * alpha-1 -and/or alpha-2 blockers * disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc) * Albuminuria \>300 mg/dag

Locations (1)

Radboud University Medical Center Nijmegen

Nijmegen, Netherlands

Outcomes

Primary Outcomes

change in central sympathetic activity

Secondary Outcomes

change in cholesterol levels, renin and aldosteron

Data from ClinicalTrials.gov

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