Intracoronary Infusion of BM-Derived Mononuclear Cells in Patients With Large Acute Myocardial Infarction

Inclusion Criteria: * Age ≥20 and \<80 years old * Acute myocardial infarction \>2 and \<96 hours from start to reperfusion * Cumulative ST-segment elevation \>6 mm on 12 lead ECG * No functional myocardial impairment outside the myocardial infarction region * Succesful PCI of infarct related coronary artery * Left ventricular ejection fraction \<50% on ventriculography, echo or MRI * Accepted anticonceptive use during the study for women of childbearing potential * Written and signed informed consent Exclusion Criteria: * CPR \> 10 minuts or persistent cardiogenic shock * complete left bundle branch block without concordant ST-segment elevation * Need foor cardiac surgery (valvular, coronary or other) * Trombocytopenia, coagulation disorders or hematological disease * History or active malignancy * Life expectancy (apart from acute myocardial infarction) \<5 years * Dialysis or severe kidney insufficiency (creatinin clearance \<30ml/') * Severe liver insufficiency * Severe respiratory disease * Systemic inflammatory pathology (acute or chronic, apart from inflammation associated with myocardial infarction) * Symptomatic cerebral or periferal vascular disease * Prior myocardial infarction or prior myocardial dysfunction * Prior CABG or heart valve surgery * Pregnancy, pregnancy wish or lactation \<1 month * Psychiatrical illness * Physical or psychological inability to adhere to the protocol * Participation in other not yet completed study