Fanconi Syndrome Due to ARVs in HIV-Infected Persons

Inclusion Criteria - Fanconi Cases Subjects must meet all of the following inclusion criteria to be eligible for participation in this study. * Adult (greater than or equal to 18 years) HIV-1 infected subjects regardless of race or ethnicity. * Subjects must be on a stable ARV regimen for greater than or equal to 1 month prior to study entry. * Evidence of protocol-defined Fanconi syndrome * TDF subjects must be on TDF-containing regimen at the time of onset of Fanconi syndrome. * Negative serum pregnancy test (females of child-bearing potential only). * Less than two years post-menopausal women of child-bearing potential (TDF subjects only) agree to follow an adequate birth control barrier method or agree to abstain from heterosexual intercourse while participating in the study. * The ability to understand and sign a written informed consent form, which must be obtained prior to initiation of any study procedures. Exclusion Criteria - Fanconi Cases Subjects who meet any of the following exclusion criteria are not to be enrolled in this study. * Non TDF subjects who have received any TDF within the prior 6 months, or those who have received greater than 2 weeks cumulative treatment. * TDF subjects who have previously served as a TDF control for this protocol. * History of current alcohol or substance abuse judged by the investigator to potentially interfere with laboratory results. Inclusion Criteria - Controls Subjects must meet all of the following inclusion criteria to be eligible for participation in this study. * Adult (greater than or equal to 18 years) HIV-1 infected subjects regardless of race or ethnicity. * No evidence of protocol-defined Fanconi syndrome * On a TDF-containing regimen matched to a Fanconi case by clinic location, duration on TDF and age. * Negative serum pregnancy test (females of child-bearing potential only). * The ability to understand and sign a written informed consent form, which must be obtained prior to initiation of any study procedures. Exclusion Criteria - Controls Subjects who meet the following exclusion criteria are not to be enrolled in this study. • History of current alcohol or substance abuse judged by the investigator to potentially interfere with laboratory results.