Gemcitabine With or Without WX-671 in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed By Surgery

DISEASE CHARACTERISTICS: * Inclusion criteria: * Locally advanced, unresectable, non-metastatic, histologically proven pancreatic adenocarcinoma (lymph nodes will not be considered metastases) * Exclusion criteria: * Any distant metastases PATIENT CHARACTERISTICS: * Inclusion criteria: * ECOG performance status ≤ 1 * Life expectancy \> 12 weeks * Normal 12-lead ECG or only clinically insignificant abnormalities in the judgment of the investigator * Female patients of child-bearing potential will be required to use an effective method of birth control for the duration of the study to prevent pregnancy * ANC ≥ 1,500/mm³ * Platelet count ≥ 100,000/mm³ * Hemoglobin ≥ 9 g/dL * Total bilirubin ≤ 1.5 times ULN * AST and ALT ≤ 2.5 times ULN * Alkaline phosphatase ≤ 2.5 times ULN * Creatinine ≤ 2 times ULN or creatinine clearance \> 45 mL/min * Exclusion criteria: * History of or current primary blood coagulation or bleeding disorders such as hemophilia * Any unrelated illness, e.g., active infection, inflammation, medical condition or laboratory abnormalities, which in the judgment of the investigator might significantly affect the patient's study participation * Any surgical or medical condition that might significantly alter the absorption, distribution, metabolism or excretion of any drug * Significant cardiac insufficiency (NYHA classification III or IV), presence of unstable angina or myocardial infarction within the previous 6 months, use of ongoing maintenance therapy for life threatening arrhythmia or known pulmonary hypertension * Any secondary malignancies within the last 5 years except for surgically cured non-melanoma skin cancer or cervical carcinoma in situ * Pregnancy (positive serum pregnancy test) or lactation * Known hepatitis B/C or HIV infection * Known hypersensitivity to any of the components in the anti-uPA serine protease inhibitor WX-671 capsules or gemcitabine hydrochloride infusion or other medical reasons for not being able to receive adequate pre-medication (for example, antihistamine or anti-inflammatory agents) PRIOR CONCURRENT THERAPY: * Permitted: * Growth factors for treatment (not prophylaxis, i.e., epoetin alfa), analgesics, blood transfusions, antibiotics, bisphosphonates, other hormonal therapy for contraceptive practice, replacement therapy such as thyroid replacement or adrenal insufficiency as appropriate and medications for acute or chronic conditions not listed under the exclusion criteria * Embolization (i.e. for hematuria) * Subjects can receive blood transfusions as medically appropriate during the study * Subjects who require a blood transfusion during screening must have stable hemoglobin (≥9.0 g/dL \[5.6 mmol/L\]) without the need for further transfusions within 2 weeks before the first dose of anti-uPA serine protease inhibitor WX-671 to remain eligible * Prophylactic use of growth factors to support neutrophils * Prohibited: * Anticoagulant or thrombolytic therapy within four weeks prior to start of treatment (except low dose anticoagulant therapy with unfractionated heparin ≤ 15000 IU/d, low molecular weight heparin ≤ 5000 IE anti-Xa activity or acetyl salicylic acid ≤ 100 mg/d at the discretion of the investigator) * Anticancer therapies such as biologic therapy and chemotherapy (other than study drugs) * Radiation therapy (during the treatment phase of the protocol; increased bone pain not controlled by medication and requiring palliative therapy will be considered disease progression) * Laser treatment * Any other investigational agent * Thalidomide * Immunosuppressive therapies (inhaled or replacement dose corticosteroids are permitted).