Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD

Inclusion Criteria: 1. Patients must be age 50 years or older 2. Patients must have predominantly classic, minimally classic or occult with no classic lesions secondary to Age Related Macular Degeneration. 3. The study eye must have ETDRS best corrected visual acuity of 69 to 24 letters (20/40 to 20/320 Snellen equivalent). 4. Patients must be willing and able to return for scheduled monthly follow-up visits for two-years. Exclusion Criteria: 1. Prior pharmacologic treatment for AMD in the study (patients can not have previously received Avastin®/Lucentis®, Macugen®, or any other anti-VEGF agents, steroid treatments, PDT, radiation treatment, or any experimental therapies for AMD in the study eye) 2. Any intraocular surgery of the study eye within 12 weeks of screening 3. Previous posterior vitrectomy of the study eye 4. Advanced glaucoma or intraocular pressure above 22 mm Hg in the study eye despite treatment.