A Study of the Effects of Ketoconazole Taken Orally Has on the PK Profiles of a Dose of GSK189075 in Healthy Volunteers

Inclusion Criteria: * Are a healthy, non-smoking male or female. * Are 18 to 55 years old, inclusive. * Have a body weight of \> or equal to 110 pounds. * Are a female who is unable to have any more children and have a negative pregnancy test. * Are willing and able to provide written informed consent before the start of any study-related procedures. * Are able to understand and comply with protocol requirements, instructions, and protocol-stated restrictions. Exclusion Criteria: * Smoke or use any tobacco products. * Have a known allergic reaction to ketoconazole or study drug. * Have a history of regular alcohol consumption greater than 7 drinks per week for females or greater than 14 drinks per week for males. * Have a positive drug or alcohol or smoking test at screening or check-in to the clinic. * Have participated in another clinical trial within 30 days prior to screening in which you have received an investigational drug. * Have donated a pint of blood within 56 days before the first dose of study drug. * Have any known or suspected stomach condition (or stomach surgery within the 6 months prior to dosing). * Have abnormal liver test results. * Have a documented history or diagnosis of cirrhosis. * Have positive results for hepatitis C or B, or HIV at screening. * Have blood pressure outside of the normal range. * Are a male subject who is unwilling to either abstain from sexual activity or unwilling to use birth control during the course of the study. * Are using non-prescription drugs, vitamins, herbal or dietary supplements (including St John's Wort) within 7 days before the first dose of study medication, * Have any abnormality identified on the screening physical or laboratory examination that the study physician feels would make it inappropriate for you to participate in the study.