Immunotherapy With Depigmented and Polymerized Allergen Extract of Phleum Pratense

Inclusion Criteria: * Positive clinical history of allergy to Phleum pratense * Patients of both gender aged from 12 up to 50 years. * Positive prick test to Phleum pratense allergen extracts * Specific IgE to Phleum pratense * Positive clinical history of allergic rhinoconjunctivitis and/or asthma * Written informed consent. Exclusion Criteria: * Use of immunotherapy during the last four years. * Any contraindication for the use of immunotherapy in accordance with European Allergy and Clinical Immunology Immunotherapy Subcommittee criteria: * Treatment with ß-blockers * Coexistence of immunopathological diseases (e.g. of the liver, kidney, the nervous system, thyroid gland, rheumatic diseases) in which autoimmune mechanisms play a role * Patients suffering from immune deficiencies * Patients with serious psychiatric / psychological disturbances * In addition, the following was considered as exclusion criteria: * Pregnant or/ in lactation patients * Patients aspirin intolerance