2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides

Khon Kaen University100 enrolled

Overview

To compare the clinical efficacy and systemic side effects between 2.5% and 10% phenylephrine for mydriasis in diabetic patient with darkly pigmented irides.

One hundred patients with diabetes from Srinagarind Hospital Eye Clinic were enrolled and randomized into two groups by block randomization. In group I (50 patients), 1% tropicamide combined with 2.5% phenylephrine were administered to dilate pupil whereas 1% tropicamide combined with 10% phenylephrine were used in Group II (50 patients). Pupil diameter, blood pressure and heart rate were measured before and after eye drop instillations.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

100

Conditions

Diabetes Mellitus

Interventions

2.5% or 10% phenylephrineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diabetic patients Exclusion Criteria: * history of intraocular surgery or laser treatment, * any ocular diseases that might affect pupil size such as glaucoma,uveitis,Horner's syndrome, Adies' pupil, * history of allergy to any drug used, and * hypertension

Locations (1)

Srinagarind Hospital Eye Clinic

Khon Kaen, Changwat Khon Kaen, Thailand

Outcomes

Primary Outcomes

Pupil diameters were measured.

Time frame: before and after phenylephrine eye drop instillations

Secondary Outcomes

blood pressure and heart rate were measured

Time frame: before and after phenylephrine eye drop instillations

Data from ClinicalTrials.gov

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