The primary purpose of this open-label study is to investigate the interaction of ketoconazole, a liver enzyme inhibitor, on oral LBH589 in adult patients with advanced solid tumors. The extension phase of the study will evaluate the safety and efficacy of LBH589 in patients with advanced solid tumors.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
14
Nevada Cancer Institute
Las Vegas, Nevada, United States
Novartis Investigative Site
Rotterdam, Netherlands
Levels of LBH589 in the blood on days 1, 5, 8, 9 and 10 of first cycle
Time frame: 2 weeks
Safety, tolerability and efficacy of oral LBH589 throughout the study
Time frame: at least every 2 months
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