Efficacy and Safety of Statin on the Course of Progressive Smoldering Multiple Myeloma

Inclusion Criteria: 1. Patients fulfilling the criteria of SMM. (see Appendix I) 2. Patients with progressive smoldering Myeloma. (see Appendix II) 3. Age 18-80 years. 4. Signed informed consent prior to patient recruitment. Exclusion Criteria: 1. Patients fulfilling diagnostic criteria of active MM .(see Appendix I) 2. Patients fulfilling diagnostic criteria of: solitary myeloma or non secreting myeloma or oligosecretory myeloma or light chain myeloma. 3. Patients on statin treatment on the day of recruitment. 4. Patients on chemotherapy or receiving steroids. 5. Patients with any contraindication to statin treatment: * Known intolerance or hypersensitivity to statin. * SGOT or SGPT above 1.5 times of upper normal level (UNL). * CPK above UNL * Concomitant treatment with macrolides and or antifungal agents (ketoconazole) * Creatinine level above 1.5 mg% * Any severe and/or uncontrolled medical disease (i.e., uncontrolled diabetes, chronic renal disease, or active uncontrolled infection). 6. Patients with second primary malignancy (except for non melanoma skin malignancy) unless they have been disease free for at least five years. 7. Patients who have a history of alcohol or drug abuse. 8. Patients who are mentally or physically unable to comply with all aspects of the study. 9. Participation to an investigational drug trial