Derris Scandens Benth Extract VS Naproxen in Knee OA

Mahidol University120 enrolled

Overview

Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia. Previous study shown that D.Scandens Benth extract has the anti-inflammatory activity. Although NSAIDs are efficaciously in the treatment of osteoarthritis,but the GI side effect is still concerned. In this study we aim to investigate the efficacy and safety of D. Scandens Benth extract compared with Naproxen for therapy of patients with knee osteoarthritis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

120

Conditions

Knee Osteoarthritis

Interventions

Derris scandens Benth extractsDRUG

Derris scandens Benth extracts (oral) 400 mg twice per day for 4 weeks

naproxenDRUG

Naproxen 500 mg/day for 4 weeks

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>=50 yr * Known case of primary knee osteoarthritis * WOMAC pain subscale (item1) \>= 5 * signed informed consent Exclusion Criteria: * hypersensitive to NSAIDs * history of peptic ulcer or melena * unable to walk , i.e. patient with severe spinal stenosis, myocardial infarction * history of intra-articular injection of knee within 3 months * status post knee replacement

Locations (1)

Siriraj Hospital

Bangkoknoi, Bangkok, Thailand

Outcomes

Primary Outcomes

WOMAC score

Time frame: 2, 4 weeks

Secondary Outcomes

6-minute walk, Quality of Life, adverse event

Time frame: 2, 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.