A Study of the Effects of GSK189075 on PK Profiles of an Oral Contraceptive Pill When Given to Healthy Female Volunteers

Inclusion Criteria: * healthy, non-smoking menstruating female age 18 to 45 years old, inclusive. * able to take a specific oral contraceptive \& KG2107494. * female unable to have any more children, still has ovaries and uterus, and has a negative pregnancy test. * female who can have children and who has regular periods and are willing to use an oral contraceptive pill and/or have a sterile partner. Exclusion Criteria: * pregnant or a nursing female. * female subject able to have children of who is unwilling or unable to use an appropriate method of birth control at least 2 weeks prior to first dose of study drug until completion of the Follow-up visit. * Have suffered with certain infection within 4 weeks prior to the first dose of study drug