Safe Renal Function In Long Term Heart Transplanted Patients

Inclusion Criteria: * Heart Transplant patients with more than 1 year of follow-up * Creatinine lower than 3.5 mg/dl * GFR Higher than 20 ml/min (calculated with Cockcroft-Gault formula) * Cyclosporine in maintenance immunosuppressive therapy * Patient must be able to sign an approve informed consent * Prior History of acute rejection within the last 3 months * Females of childbearing age may be included if pregnancy is excluded and acceptable contraception measures are used Exclusion Criteria: * Patients who are recipients of multiple organ transplants * Prior or current use of sirolimus or everolimus * History of acute rejection within the last 6 months * Coronary Artery Bypass Surgery or other cardiac surgery in the past 3 months * Patient not able to attend all follow-up evaluations