A Phase III, Open-Label, Single-Dose Study to Evaluate the Safety and Immunogenicity of Fluviral® Vaccine

Inclusion Criteria: * Healthy male and female adults, 18 years of age and older. * Female subject of non-childbearing potential. Written informed consent obtained from subject. Exclusion Criteria: * Acute disease at the time of enrollment. * Blood pressure abnormalities. * Any immunosuppressive condition, such as HIV or cancer. * Renal impairment, hepatic dysfunction, complicated insulin-dependent diabetes mellitus. * Unstable cardiopulmonary disease requiring chronic medical therapy or associated with functional impairment. * Any demyelinating disease, including Guillain-Barré syndrome. * Alcohol consumption and/or drug abuse. * Receipt of an influenza vaccine within 9 months prior to enrollment or of any vaccines within 30 days prior to enrollment. * Any known or suspected allergy to the Fluviral vaccine.