Strict glycemic control improves mortality and morbidity of patients admitted to the postoperative intensive care unit (ICU). The investigators would like to know if this therapy could improve the long term neurologic and cognitive outcomes of patients treated for acute subarachnoid hemorrhage with either a surgical or intravascular approach.
Intensive Insulin Therapy and Strict Glycemic Control (80-120 mg/dL) Versus Standard Insulin Therapy in Neurosurgical Intensive Care Patients (Subarachnoid Hemorrhage, Traumatic Brain Injury, Intracranial Expanding Lesion): Safety, and Efficacy (Mortality, Morbidity, Long Term Neurologic Outcome).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
800
50 UI Actrapid diluted in 50 ml of saline
University of Rome La Sapienza
Rome, Italy
RECRUITINGEpisodes of hypoglycemia
Infection rate
Time frame: during the study
Vasospasm rate
Time frame: during the study
Mortality
Time frame: 6 months follow up
Neurologic status
Time frame: 6 months follow up
Vincenzo Cuzzone
CONTACT
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