Effect of N-Acetylcysteine (NAC) on Creatinine in Chronic Kidney Disease

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's60 enrolled

Overview

N-acetylcysteine is used to reduce the risk of injury to the kidney after the administration of contrast dye. The mechanism and effectiveness of this intervention is not substantiated in the literature. The investigators hypothesize that serum creatinine will be lower in patients who receive NAC compared to those who receive the placebo but serum cystatin C will not change in patients who receive NAC compared to those who receive the placebo. Also urine creatinine will increase after the administration of NAC compared to before the administration of NAC.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

QUADRUPLE

Enrollment

Conditions

Chronic Kidney Disease

Interventions

N-acetylcysteineDRUG

N-acetylcysteine 1200 mg twice daily x 48 hours

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with an eGFR between 30-60 ml/min calculated using last available creatinine and patient weight. 2. Age \> 18 3. No known allergies to or adverse effects from NAC 4. No known scheduled radio-contrast procedures 5. No medications known to affect creatinine secretion

Effect of N-Acetylcysteine (NAC) on Creatinine in Chronic Kidney Disease

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes