Standard treatment of patients with acute ST-segment elevation myocardial infarction consist of acute re-opening of the occluded coronary artery (primary PCI). Despite successful treatment of the epicardial vessel reperfusion is sometimes inadequate leading to large final infarct sizes. This phenomenon is known as the reperfusion injury. Several animal studies have indicated that graded re-opening of the artery may limit tissue damage. Generally this is referred to as mechanical postconditioning. The study investigates the effect on final infarct size evaluated by magnetic resonance scan of postconditioning of ST-segment elevation myocardial infarctions. Mechanical postconditioning is performed by means of several balloon inflations in the injured vessel following its acute re-opening.
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Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
200
Acute re-opening of the occluded coronary artery
Mechanical postconditioning with 4 cycles 30/30 sek balloon inflations
Cardiac Catherization Lab., Heart Center, Rigshospitalet, University of Copenhagen
Copenhagen, Denmark
Final infarct size evaluated by MR
Time frame: 3 month
MACE (death, re-infarction, TLR)
Time frame: 1, 15 month
Stent thrombosis
Time frame: 15 month
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