The purpose of this study is to determine optimal prophylactic antibiotics administration method in elective laparoscopic colorectal surgery.
The use of antibiotic prophylaxis in patients who undergo elective colorectal surgery is now accepted universally. But the rout of administration should be systematic, oral, or both is controversial. Furthermore, although many trails have been performed, no trial limited to laparoscopic surgery is performed. We compare 2 approaches - oral and systemic versus systemic antibiotic prophylaxis - in limited to elective laparoscopic colorectal surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
584
Intravenous dose of 1g cefmetazole just before surgery and additional doses every 3hs during surgery
2 doses of oral kanamycin(1g)/ metronidazole(750mg) administration on the day before surgery with intravenous dose of 1g cefmetazole just before surgery and additional doses every 3hs during surgery
Kyoto Univercity Hospital
Kyoto, Kyoto, Japan
National Hospital Organization, Kyoto Medical Center
Kyoto, Kyoto, Japan
Kyoto Katsura Hospital
Kyoto, Kyoto, Japan
Tenriyorozu Hospital
Tenri, Nara, Japan
Incidence and classification of surgical site infection (SSI)
Time frame: Within the first 30 days after surgery
Incidence of colitis, other infectious diseases and other postoperative complications.
Time frame: Within the first 30 days after surgery
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Kitano Hospital
Osaka, Osaka, Japan