Chronic Inflammatory Activation in Fat Tissue: an Atherogenic Factor in Stable Coronary Artery Disease

Inclusion Criteria: * either impaired glucose tolerance (2-h plasma glucose concentration \>7.8 and \<11.1 mmol/L during an oral glucose tolerance test) or impaired fasting glucose (fasting glucose concentration \>6.0 and \<7.0 mmol/L) * coronary artery disease determined by coronary angiography * BMI \> 25 * male patients aged 35-75 years Exclusion Criteria: * diabetes mellitus type 1 * diabetes mellitus type 2 in combination with glycosylates hemoglobin \>6.0%, previous medication with oral antidiabetic agents or insulin, fasting plasma glucose concentration \> 11.0 mmol/L * unstable angina pectoris * indication for coronary artery bypass graft operation * myocardial infarction within the last 3 months * reduced left-ventricular systolic function \< 40 %