A Study in Sepsis Patients With Renal Failure

Inclusion Criteria: * Patients between the age of 18 and 80 years. * Proven or suspected infection. * Two out of four SIRS criteria of systemic inflammation, existing for less than 24 hours after admission in the intensive care unit, as follows: * Core temperature higher then 38 degree Celsius or lower then 36 degree Celsius. * Heart rate above 90 beats/min (unless the patient has a medical condition known to increase heart rate or is receiving treatment that would prevent tachycardia). * Respiratory rate above 20 breaths/min, a PaCO2 lower then 32mmHg or the use of mechanical ventilation for an acute respiratory process. * White-cell count above 12,000/mm3 or below 4,000/mm3 or a differential count showing \>10 percent immature neutrophils. * Acute renal failure, defined as * Rise in serum creatinine level to ≥150μmol/L within the previous 48 hours, in the absence of primary underlying renal disease OR * Minimally a stage 1 Kidney Injury according to AKIN creatinine criteria: Increase in serum creatinine ≥26.2µmol/L (0.3mg/dL) or increase to ≥150% (≥1.5 -fold) from baseline in the previous 48 hours in the absence of primary underlying renal disease and where baseline creatinine is less than 150 µmol/L) OR * Minimally a stage 1 Kidney Injury according to AKIN Urine Output criteria: Urine Output of ≤ 0.5mg/kg/h for ≥6h and following adequate fluid resuscitation when applicable, in the absence of underlying primary renal disease and where baseline creatinine is less than 150µmol/L) * Written informed consent obtained prior to any study intervention. Exclusion Criteria: * Pregnant women or nursing mothers and fecund females who are not on effective contraception (chemical: pill; or mechanical: IUD) * Patients already on dialysis (RTT) at entry * Known HIV (sero-positive) patients * Patients receiving immunosuppressant therapy or on chronic high doses of steroids equivalent to prednisone 1mg/Kg/day * Patients expected to have rapidly fatal disease within 24 hours * Known confirmed gram-positive sepsis * Known confirmed fungal sepsis * Acute pancreatitis with no established source of infection * Patients not expected to survive for 28 days due to other medical conditions such as end-stage neoplasm or other diseases * Participation in another investigational study within 90 days prior to start of the study which might interfere with this study * Any previous administration of active study medication. * Known allergy for dairy (bovine) products including cow milk. * Sepsis without renal failure as defined in the Entry Criteria. * History of chronic renal failure or history of persistent creatinine level equal or greater than 150umol/L prior to entry for reasons other than the current sepsis condition".