Efficacy and Safety of Quetiapine in Treating Affective Symptoms of Patients With First-episode psychosis-a Pilot Study

Inclusion Criteria: All patients who meet the following inclusion criteria are eligible to participate in the study: * male and female patients with first-episode schizophrenia (based on ICD-10 criteria) * in- and out-patients * age between 18 and 45 * verbal IQ 85 * given written informed consent Exclusion Criteria: Patients who meet one or more of the following exclusion criteria cannot participate in the study: * Other Psychiatric disorders not in full remission, concomitant organic mental disorder or mental retardation * Patients who, in the investigators judgement, pose an imminent risk of suicide or a danger to self or others * Hamilton Depression Rating Scale\<7 points * Female patients who are pregnant, lactating or at risk of pregnancy * Female patients who are not using a highly effective method of birth control. A highly effective method of birth control is defined as those which results in a low failure rate (i.e. less than 1% per year) when used consistently and correctly such as implantants, injectables, combined oral contraceptives, some IUDs, sexual abstinence or vasectomised partner. For subjects using a hormonal contraceptive method, information regarding the product under investigation and its potential effect on the contraception must be addressed. * history of idiopathic orthostatic hypotension, or condition that would predispose to (dehydration, hypovolaemia) * Risk of transmitting human immunodeficiency virus (HIV) or hepatitis B and C, via blood or other body fluids * history of non-compliance as judged by the investigator * Patients with substance dependence. A urine drug screen will be performed. The investigator will evaluate the results along with medical history to determine if the patient meets the DSM-IV criteria for substance dependence * Patients with known diabetes mellitus or impaired glucose tolerance, especially a patient with Diabetes Mellitus (DM) fulfilling one of the following criteria: * unstable DM defined as enrollment glycosylated hemoglobin (HbA1c)\>8.5% * patients admitted to hospital for treatment of DM or DM related illness in past 12 weeks * patients not under physicians care for DM * physicians responsible for patient´s DM care has not indicated that patient´s DM is controlled * physician responsible for patient´s DM care has not approved patient´s participation in the study * patient has not been on the same dose of oral hypoglycemic drug(s) and/or diet for the 4 weeks prior to randomization. (For thiazolidinediones (glitazones) this period should not be less than 8 weeks) * patients taking insulin whose daily dose on one occasion in the past 4 weeks has been more than 10% above or below their mean dose in the preceding 4 weeks. Note: If a diabetic patient meets one of these criteria, the patient is to be excluded even if the treating physician believes that the patient is stable and can participate in the study. * ECG considered to show clinical significant abnormalities at enrolment as determined by a cardiologist * Use of drugs that induce or inhibit the hepatic metabolizing cytochrome 3A4 enzyme within 2 weeks prior to randomization (e.g. inducers: phenytoin, carbamazepine, phenobarbital, rifampicin, rifabutin, glucocorticoids, thioridazine and St. Johns´wort (=Johanniskraut) and inhibitors: ketaconazole (except for topical use), itraconazole, fluconazole, erythromycin, clarithromycin, fluvoxamine, nefazodone, troleandomycin, indinavir, nelfinavir and saquinavir). * patients with insufficient knowledge of the German language * A thyroid-stimulating hormone (TSH) concentration more than 10% above the upper limit of the normal range and the laboratory used for sample analysis at enrolment, whether or not the subject is being treated for hypothyroidism * Any serious and unstable somatic illness (e.g. malignant tumor, severe cardiovascular disease, etc.) that, in the opinion of the investigator, would be negatively affected by the study medication or that would affect study medication. If relevant medical findings are obtained during the examination, it is at the physician's discretion to initiate additional examinations (e.g. lab testing, ECG). If medically indicated examinations have already been carried out, the results should not be older than two weeks at the time of the screening visit. The patient can only participate in the study if all study results are within the normal range or the examiner has determined a deviation as clinically irrelevant. This should be clearly documented in the CRF. * Participation in another drug trial within 4 weeks prior to enrolment into this study or longer in accordance with local requirements