Moderate Weight Loss Makes Obese Patients With Severe Chronic Plaque Psoriasis Responsive to Sub-Optimal Dose of Cyclosporine: an Investigator Blinded, Controlled, Randomized Clinical Trial

Inclusion Criteria: * 18 years of age,active but clinically stable plaque psoriasis involving at least 10 percent of the body surface area and a psoriasis area and severity index (PASI) score ≥10 and a body mass index ≥30. Exclusion Criteria: * Other type of psoriasis (guttate, erythrodermic and pustular psoriasis) * Uncontrolled hypertension * Severe congestive heart failure * Renal and liver impairment * Active or chronic infections, including HIV, HBV and HCV infections, latent tuberculosis * Previous or active malignancies * Pregnancy and lactations * Previous treatment with cyclosporine * Phototherapy or any systemic or topical therapy for psoriasis within the previous 4 weeks before enrolment.