Ghrelin Decreases Insulin Sensitivity

University of Aarhus8 enrolled

Overview

Ghrelin administration increases appetite and, in rodents, induces weight gain. The aim of this study is to investigate the effect of short term ghrelin administration to humans on metabolism.

The current study is initiated in order to assess the impact of acute ghrelin administration on insulin resistance measured by a hyperinsulinemic euglycemic clamp. Second, as free fatty acid is the predominant substrate during fasting, we aim to asses the effects of ghrelin on local and systemic lipolysis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE

Enrollment

Conditions

Healthy Subjects

Interventions

Ghrelin and saline (as placebo)DRUG

Intravenous infusion

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy men, age \>= 18 yr age \< 50 yr, body mass index \< 27.5 kg/m2above or equal to 18 yr Exclusion Criteria: * any disease, use of prescribed medication, age \< 18 yr or \>= 50 yr

Outcomes

Primary Outcomes

Insulin sensitivity

Time frame: End of clamp period

Secondary Outcomes

Effects on lipolysis

Time frame: End of basal and end og clamp period

Data from ClinicalTrials.gov

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