Study on the Prognosis and Effect of Anti-diabetic Drugs on Type-2 Diabetes Mellitus With Coronary Artery Disease

Shanghai Jiao Tong University School of Medicine304 enrolled

Overview

The purpose of this study is to explore the recurrence risk of cardiovascular events in patients with type 2 diabetes mellitus and coronary heart disease after different antidiabetic drug therapy (glipizide or metformin) by using an double-blind, randomized, parallel control and prospective study The end point of this study is: 1. follow up 3yr 2. recurrence of cardiovascular event 3. death caused by other reasons such as stroke, uremia, blindness and amputation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

304

Conditions

Type 2 Diabetes Coronary Artery Disease

Interventions

Eligibility

Sex: ALLMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Coronary heart disease * Type 2 diabetes Exclusion Criteria: * Severe organ dysfunction, psychopathy, infection, neutropenia * Congenital heart disease, rheumatic heart disease, severe arrhythmia, myocardiopathy

Outcomes

Primary Outcomes

Composite of cardiovascular events which were defined as death from a cardiovascular cause, death from any cause, nonfatal myocardial infarction, nonfatal stroke or arterial revascularization

Secondary Outcomes

New or worsening angina

new or worsening heart failure

new critical cardiac arrhythmia

new peripheral vascular events