Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2

Inclusion Criteria: * diagnosed as 2- or 3-walled vertical intrabony defect \>=3 mm deep from the top of the remaining alveolar bone * with mobility of the tooth of degree 2 or less * with width of attached gingiva appropriate for Guided Tissue Regeneration Exclusion Criteria: * concomitant administration of adrenal cortical steroid within 4 wks after the surgery * administeration of calcium antagonist during the 4 weeks preceding administration of the investigational drug * coexisting malignant tumour or history of the same * coexisting diabetes (HbA1C \>= 6.5%) * an extremely poor nutritional condition (serum albumin concentration \<2 g/dL) * pregnancy or lactation