One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

University of Zurich76 enrolled

Overview

One-lung ventilation; organ protection; volatile anesthetics One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study: 1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse? 2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium. * Trial with immunomodulatory product / biological

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Thoracic Surgery With One-lung Ventilation

Interventions

Sevoflurane/propofol

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion criteria: * Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation Exclusion criteria: * Immunosuppressive therapy * Ongoing inflammatory processes

Locations (1)

University Hospital of Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

One-lung ventilation measurement in the re-ventilated lung after short-period pulmonary collapse

Time frame: Sep 07

Data from ClinicalTrials.gov

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