Role of Volatile Anesthetics for Hepatic Protection

University of Zurich

Overview

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Conditions

Reperfusion Injury

Interventions

SevofluraneDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Older than 18 years of age * Patients undergoing liver resection (benign or malignant tumors) Exclusion Criteria: * Laparoscopic liver resection coagulopathy (platelets \< 50,000/ml, Quick \< 50%) * Liver cirrhosis

Locations (1)

University Hospital of Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Blood levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT)

Data from ClinicalTrials.gov

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