Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients

Hospital Authority, Hong Kong200 enrolled

Overview

The purpose of this study is to evaluate the efficacy of rabeprazole (pariet) versus placebo in treating reflux laryngitis in Chinese patients. Patients who attend the voice clinic of Department of ENT, Queen Mary hospital with suspected reflux laryngitis will be recruited. A questionnaire will be administered by the research assistant of the Department of Medicine and ENT, Queen Mary hospital. A 12-week course of PPI versus placebo trial will be commenced and patients' symptoms and signs will be documented at 6-week and 12-week time. The study will finish after a 12-week course of rabeprazole.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

200

Conditions

Gastroesophageal Reflux Laryngitis

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ambulatory patients with age between 18-80 years old * Patients with newly presented laryngitis. Exclusion Criteria: * They were under 18 or over 80 years of age * Has significant concomitant medical disease * Pregnancy or lactating women * Chronic cough attributable to known chronic pulmonary or tracheobronchial disease * Previous glottal surgery, radiotherapy or malignancy * Acid suppressive therapy within 4 wk prior to recruitment * Pharyngo-laryngeal infection in the previous 3 months * Tracheal intubation in previous 12 months * Immunosuppression and use of inhaled corticosteroid

Outcomes

Primary Outcomes

Symptoms assessment, quality of life.

Time frame: 12 weeks

Secondary Outcomes

Compliance

Time frame: 4 weeks

Adverse effects