Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan

Università degli Studi dell'Insubria80 enrolled

Overview

Aim of the study is to compare in hypertensive patients the effect of one year therapy with ACE-inhibitor (RAMIPRIL) or angiotensin II receptor blocker (IRBESARTAN) on left atrial remodelling and diastolic function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Left Atrial Volume Hypertensive Heart Disease Antihypertensive Drugs Diastolic Function Renin Angiotensin System

Interventions

ramiprilDRUG

ramipril 2.5- 5 mg once daily

irbesartanDRUG

irbesartan 150-300 mg once daily

Eligibility

Sex: ALLMin age: 40 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria:· * mild to moderate essential hypertension * no antihypertensive treatment * good quality echocardiogram Exclusion Criteria: * cardiovascular diseases (AMI, stroke o TIA) * heart failure, valvular heart disease * diabetes * secondary hypertension * atrial fibrillation * hepatic and renal severe failure * pregnancy

Locations (1)

University of Insubria-Department of Clinical Medicine

Varese, Italy

RECRUITING

Outcomes

Primary Outcomes

left atrial volume

Time frame: one year

diastolic function

Time frame: one year

Secondary Outcomes

systolic and diastolic blood pressure

Time frame: one year

Data from ClinicalTrials.gov

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