Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure

Centro Cardiologico Monzino20 enrolled

Overview

To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure. Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Enrollment

Conditions

Chronic Heart Failure

Interventions

acetazolamideDRUG

i.v. 500 mg of acetazolamide for the acute study and 500 mg of acetazolamide p.o. t.i.d. for two days

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * chronic heart failure in stable clinical condition * exercise-induced periodic breathing Exclusion Criteria: * comorbidities * NYHA class IV

Locations (1)

Centro Cardiologico Monzino, University of Milan

Milan, Italy

Outcomes

Primary Outcomes

Suppression of periodic breathing

Time frame: two days

Secondary Outcomes

suppression of sleeping apnea

Time frame: two days

Data from ClinicalTrials.gov

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