The efficacy of chimiotherapy in cervix epithelial cancer is low even with the association cisplatine - topotecan . News thérapeutics are needed in the goal of increase the survival and quality of life in patients with cervix cancer. Cetuximab has shown the potentialisation on the efficacy of cisplatine and irinotecan. Cisplatine and topotecan have shown an efficacy in cervix cancer. Cetuximab is well tolerate. Many clinical trials shown the faisability of the association of cetuximab and cisplatine in cancer. Many clinical trials have shown the faisability of association of cetuximab and irinotecan in colorectals metastatiques cancers .
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
44
400 mg/m² 2h injection at week 1, then 250 mg/m² in one hour injection the following weeks
CRLC Val d'Aurelle
Montpellier, France
Hôpital HOTEL DIEU
Paris, France
Oncologie, Hôtel-Dieu, 1 place du parvis Notre-Dame
Paris, France
Centre Claudius Régaud
Toulouse, France
responses rate regarding the RECIST criteria.
Time frame: up to progression
Quality of life, free interval, safety.
Time frame: up to progression
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