Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)

Inclusion Criteria: * Participant is scheduled to undergo cardiothoracic surgery involving a full median sternotomy (not including cardiac transplantation surgery) within 14 to 60 days after vaccination. * Female participants of reproductive potential are required to have a negative urine or serum pregnancy test immediately prior to study vaccination and must use an acceptable form of birth control. Exclusion Criteria: * Participants had an invasive Staphylococcus aureus infection within the past 3 months prior to study entry. * A realistic (\>50%) possibility that cardiothoracic surgery will be necessary sooner than 10 days after vaccination. * Participant is planning to undergo cardiac transplantation surgery or sternal debridement to remedy an infection resulting from a prior cardiothoracic surgery. * Participant has any type of ventricular-assist device in place at the time of study entry. * Participant has a history of anaphylaxis to any of the vaccine components. * Participant received V710 vaccine, any other investigational Staphylococcus aureus vaccine, or investigational Staphylococcus aureus antibodies. * Participant has a temperature of ≥100.4ºF (≥38.0ºC), oral equivalent, within 48 hours prior to study vaccination. * Participant has impairment of the immune system. * Participant has a medical condition in which the expected survival is less than 90 days.