This study will measure the effects of different doses of aliskiren on kidney blood flow and function in healthy adults and determine how salt intake affects the response to aliskiren.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
32
Brigham and Women's Hospital
Boston, Massachusetts, United States
Renal plasma flow following 3 single doses of aliskiren in healthy volunteers on a low sodium(10 mEq/day)diet
Time frame: baseline and hourly intervals.
Single dose application of aliskiren on renal hemodynamics and circulating markers of the renin pathway
Time frame: baseline, and at 5 hours, and 24 hours post dose
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