With the incremental trend of benign breast tumor, the surgical process of mastectomy was proceeded too much every day, especially in the Maternal Health Care Hospital, but whether the investigators can find another way to relieve the postoperative pain after such an operation is still unknown. The investigators hypothesized that the pain from the relatively small surgery may not be significant compared to different treatments, even if no drug was delivered to them. The investigators are enrolling patients who underwent mastectomy from benign breast tumor, and are observing the analgesic effects of different drugs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
2,000
Saline 5 ml administrated intravenously
Butorphanol tartrate 1 mg i.v.
Butorphanol Tartrate 2 mg i.v.
Flurbiprofen Axetil 50 mg i.v.
Flurbiprofen Axetil 100 mg i.v.
Tramadol Hydrochloride 10 mg i.v.
Tramadol Hydrochloride 20 mg i.v.
Nanjing Maternal and Child Care Hospital
Nanjing, Jiangsu, China
Visual analog scale (VAS) rating of pain
Time frame: 0-24h after surgeries
VAS rating of sedation
Time frame: 0h to 24h after the end of the operation
Overall VAS rating of satisfaction with analgesia
Time frame: 24 h after operation
Incidence of side effects
Time frame: From the initiation of analgesia (0 h) to the end of the study (24 h postoperative)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.