Safety Study of ISIS 325568 in Healthy Volunteers

Inclusion Criteria: 1. Age 18 to 65 years 2. Males or females. Females must be non-pregnant and non-lactating, and either surgically sterile (hysterectomy, oophorectomy, or tubal ligation) or post-menopausal. Males must be surgically sterile, abstinent or if engaged in sexual relations of child-bearing potential, subject or partner must be using an acceptable contraceptive method during the trial and for 9 weeks after the last dose of study drug. 3. Give written informed consent to participate in study and availability for all study requirements 4. Fasting plasma glucose ≤ the upper limit of the laboratory's reference range (ULN) 5. HbA1C ≤ ULN 6. BMI \< 30 kg/m2 Exclusion Criteria: 1. Clinically significant abnormalities in medical history or physical examination 2. Abnormalities on laboratory examination (ALT \> ULN, AST \> ULN, bilirubin \> ULN, creatinine \> ULN, urine protein positive by urine dipstick, platelets \< lower limit of normal and any other clinically significant laboratory findings) 3. History of clinically significant abnormalities in coagulation parameters 4. Positive test result for HIV, hepatitis B virus, and/or hepatitis C virus 5. Active infection requiring antiviral or antimicrobial therapy 6. Subjects on chronic or acute prescription medication may be permitted after discussion with the Isis Medical Monitor. 7. Malignancy (with the exception of basal or squamous cell carcinoma of the skin if adequately treated and no recurrence for \> 1 year) 8. Any other concurrent condition which, in the opinion of the Investigator, would preclude participation in this study or interfere with compliance 9. History of alcohol or drug abuse 10. Undergoing or have undergone treatment with another investigational drug, biologic agent or device within 90 days prior to Screening. 11. Blood donation within three months of screening