The purpose of this study will be to examine the safety and efficacy of modafinil in increasing number of methamphetamine non-use weeks in subjects with methamphetamine dependence.
To evaluate the efficacy and safety of modafinil in reducing methamphetamine use in subjects with methamphetamine dependence. It is hypothesized that modafinil, compared to placebo, will be associated with an increase in the number of methamphetamine non-use weeks over time as measured by quantitative urine analysis for methamphetamine.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
210
South Bay Treatment Center
San Diego, California, United States
Matrix Institute on Addictions
Tarzana, California, United States
Torrance Site
Torrance, California, United States
University of Colorado Health Sciences Center
Denver, Colorado, United States
Abstinence (Week 1 - 12)
Number of participant who abstained from methamphetamine from weeks 1 through 12
Time frame: Weeks 1 - 12
Reduction of Craving
Number of subjects with 21 or more consecutive days of abstinence
Time frame: 21 days
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