Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial

Phase 4CompletedNCT00520338

Mahidol University80 enrolled

Overview

The purpose of this study is to determine whether celecoxib is effective in the treatment postoperative pain after thyroidectomy. The research hypothesis: There is a difference in postoperative morphine consumption in the first 24 hours after thyroidectomy between patients who received celecoxib or placebo.

Postoperative pain has been concerned in the past few years by both the anesthesiologists ans the surgeons. COX2-inhibitors have played an important roles in postoperative pain with minimal side effects. Comparison(s): There is a difference in postoperative morphine consumption in the first 24 hours after thyroidectomy between patients who received celecoxib and placebo.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain Thyroidectomy Cyclooxygenase 2 Inhibitors

Interventions

celecoxibDRUG

1. placebo 2. celecoxib 400 mg oral single dose

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient ASA physical status I-III. 2. Scheduled for an elective thyroidectomy. 3. Body weight \> or = 40kg 4. Can operate a patient-controlled analgesia (PCA) device. Exclusion Criteria: 1. History of asthma, acute rhinitis, nasal polyps, angioneurotic edema or urticaria following the administration of aspirin or other NSAIDs. 2. Known hypersensitivity to morphine or sulfonamides. 3. History of hepatic dysfunction. 4. Creatinine clearance \< 30ml/min. 5. History of bleeding tendency. 6. History of gastrointestinal bleeding or active peptic ulcer. 7. Known case of inflammatory bowel disease. 8. Patient with severe heart failure.

Locations (1)

Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, Thailand

Outcomes

Primary Outcomes

The patients' total amount of morphine requirement in the first 24 hour.

Time frame: 24 hour

Data from ClinicalTrials.gov

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