Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

Centre Hospitalier Universitaire de Saint Etienne45 enrolled

Overview

Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Glomerulonephritis, IGA

Interventions

gene transcription and cytometryPROCEDURE

samply of 30 ml of blood

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with pathogenesis of Berger's disease confirmed by renal biopsy * Glomerular filtration \> 60 ml/min/1,73m2 * Written informed consent * Patient affiliated to social insurance Exclusion Criteria: * Immunosuppressor treatment within 6 months before the study inclusion * Clinical infection within 2 months before the study inclusion * C-reactive protein (CRP) \> 10 mgL-1

Locations (1)

Nephrology Unit Hôpital Nord CHU de Saint-Etienne

Saint-Etienne, France

Outcomes

Primary Outcomes

proportion averages of cells CD4+CD25+CD127 low T in peripheral blood

Time frame: inclusion

Secondary Outcomes

average relative expression of genes FoxP3, CTLA4, GITR, IL10, TGF-B, OX40, TIM-1, and TIM-3

Time frame: inclusion

Data from ClinicalTrials.gov

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