Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Trial

N/ACompletedNCT00522028

Oslo University Hospital191 enrolled

Overview

The present study is a randomized, controlled trial that investigates the effects of parathyroidectomy or medical observation in mild asymptomatic pHPT on morbidity and quality of life (QoL).

The patients are included and randomized by block randomization to medical observation or parathyroidectomy by an experienced parathyroid surgeon. The patients will be followed up for 10 years.

Study Type

OBSERVATIONAL

Enrollment

191

Conditions

Primary Hyperparathyroidism

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Untreated, asymptomatic pHPT * 2.60\>S-Ca\<2.85 mmol/liter * Age between 50 and 80 yr * No medications interfering with Ca-metabolism * Informed consent Exclusion Criteria: * Hyperparathyroid bone disease * Previous operation in the neck * Impaired kidney function * Kidney stones * Complicating medical conditions * Psychiatric disorders * Multiple endocrine neoplasia, * Familial hypocalcuric hypercalcemia * Familial HPT

Locations (1)

Oslo University Hospital - Rikshospitalet

Oslo, Oslo County, Norway

Data from ClinicalTrials.gov

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