Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

University of Calgary8 enrolled

Overview

The purpose of this study is to: 1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury 2. Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury 3. Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Brain Injuries, Traumatic

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient is 18 years of age or older * Patient has GCS less than 9 * Patient requires intracranial pressure monitoring * Patient life expectancy greater than 72 hours Exclusion Criteria: * Patient's TBI is greater than 24 hours old * Patient is less than 18 years of age * Patient does not require intracranial pressure monitoring * Patient has life expectancy less than 72 hours * Patient has GCS greater or equal to 9 * Patient is currently enrolled in another study

Locations (1)

Foothills Medical Centre

Calgary, Alberta, Canada

RECRUITING

Central Contacts

David A Zygun, MD

CONTACT

403-944-1691 dzygun@ucalgary.ca

Data from ClinicalTrials.gov

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