Preoperative Hepatic Arterial Infusion Chemotherapy

IRCCS San Raffaele

Overview

To assess the feasibility and results of liver resection after preoperative hepatic artery infusion (HAI) chemotherapy with FUDR.

Between 1995 and 2004, 239 patients with isolated colorectal liver metastases received HAI chemotherapy with neoadjuvant intent. Fifty of these patients underwent subsequent curative liver resection (HAI group). Postoperative morbidity, liver function tests, and long term outcomes were evaluated. Adverse events related to HAI chemotherapy were also evaluated.

Study Type

OBSERVATIONAL

Conditions

Colorectal Liver Metastases

Interventions

Floxuridine FUDRDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Unresectable liver metastases * Potentially resectable liver metastases Exclusion Criteria: * Extrahepatic disease

Locations (1)

Department of Surgery - Liver Unit, Scientific Institute San Raffaele,

Milan, Italy

Data from ClinicalTrials.gov

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