Patients recovering from coronary artery bypass graft (CABG) surgery have high rates of depression, and depression is associated with higher risk of complications and death. Recent discoveries show that depression involves changes in certain molecules in the blood, which are also involved in progressive coronary artery disease (CAD) and its complications. This study will evaluate the effects of cognitive behavioral therapy (CBT) as a treatment for depression on these biological markers among CABG patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
808
Subjects receive CBT in the home for 8 weeks with blood draws every other week during therapy.
Subjects receive Usual Care for 8 weeks followed by CBT
Long Beach Memorial Medical Center
Long Beach, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Kaiser Permanente Medical Center - Sunset
Los Angeles, California, United States
Department of Veterans Affairs-Greater Los Angeles Healthcare System, West Los Angeles
Los Angeles, California, United States
Levels of proinflammatory cytokines (IL-1 and IL-6)
Time frame: at baseline and after 8 weeks (at the completion of the intervention)
The soluble receptor for IL-6 (sIL-6)
Time frame: at baseline and after 8 weeks (at the completion of the intervention)
Inflammatory markers c-reactive protein (CRP and sICAM-1)
Time frame: at baseline and after 8 weeks (at the completion of the intervention)
Depression symptoms (Beck Depression Inventory)
Time frame: at baseline and after 8 weeks (at the completion of the intervention)
Presence of clinical depression
Time frame: at baseline and after 8 weeks (at the completion of the intervention)
Pain
Time frame: at baseline and after 8 weeks (at the completion of the intervention)
Sleep disturbances
Time frame: at baseline and after 8 weeks (at the completion of the intervention)
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University of California, Los Angeles School of Nursing
Los Angeles, California, United States