The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study

McGill University Health Centre/Research Institute of the McGill University Health Centre200 enrolled

Overview

Dilated cardiomyopathy (DCM) affects about 200,000 Canadians. Eighty percent of these cases are of unclear cause, often occuring in families. We believe that mutations in specific already-identified genes contribute to DCM in Quebec and that certain mutations may account for a significant proportion of cases due to the well-documented "founder effect". Two hundred patients with DCM followed in our Heart Function Clinic will be approached for one blood sample at their routine clinic visit to test this hypothesis. The samples will be tested in the Laboratory of Cardiovascular Genetics at the Royal Victoria Hospital.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Dilated Cardiomyopathy (DCM)

Interventions

blood testOTHER

looking at DNA

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Followed at MUHC Heart Function Centre * Documented EF of less than or equal to 35% and an enlarged heart with a left ventricular end-diastolic size of greater than 6 cm. * Patient's written consent Exclusion Criteria: * Patients with a known underlying condition that results in a weakened and enlarged heart * Patients unable to read and understand the consent form * Patients who do not wish to participate

The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study

Overview

Conditions

Interventions

Eligibility

Locations (1)

Central Contacts