Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract

DISEASE CHARACTERISTICS: * Histologically confirmed high-risk, premalignant lesions of the upper aerodigestive tract, meeting one of the following criteria: * Unresectable, diffuse high-grade dysplasia, defined as moderate or severe dysplasia that is not assessable by physical examination and/or that cannot be excised by standard surgical techniques * previously treated HNSCC with persistent or recurrent high grade dysplasia with no evidence of head and neck malignancy for three months prior to enrollment or who have successfully completed therapy for head and neck malignancy more than 3 months prior to enrollment. * Dysplastic lesions with 3p or 9p loss of heterozygosity * Disease location amenable to endoscopic biopsy in an outpatient clinical setting or operative biopsy within the routine scheduling and practice of clinical care * No medical contraindication to biopsy of the target lesion * Pathology must be reviewed by the Johns Hopkins Hospital Department of Pathology PATIENT CHARACTERISTICS: * Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Absolute neutrophil count (ANC) \> 1,000/mm³ * Platelet count \> 75,000/mm³ * Creatinine clearance \> 60 mL/min * Total serum bilirubin \< 1.5 mg/dL * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception during and for 3 months after completion of study therapy * No concurrent illness likely to preclude study therapy or surgical resection * Patients with a history of a curatively treated malignancy are eligible provided they are disease-free and have a survival prognosis that exceeds 5 years * No evidence of clinically active interstitial lung disease * Patients with chronic, stable radiographic changes who are asymptomatic are eligible * No history or radiological evidence of pulmonary fibrosis * No acute myocardial infarction within the past 3 months * No uncontrolled angina, arrhythmia, or congestive heart failure * No evidence of other severe or uncontrolled systemic disease (e.g., unstable or uncompensated respiratory, cardiac, hepatic, or renal disease) * No evidence of any other significant clinical disorder or laboratory finding that would preclude study participation * No known severe hypersensitivity to cetuximab or any of its excipients * No prior hypersensitivity reaction to chimerized or murine monoclonal antibody therapy * No severe abnormality of the cornea PRIOR CONCURRENT THERAPY: * See Disease Characteristics * Recovered from prior oncologic or other major surgery or biopsy * More than 30 days since prior non-approved or investigational drugs * No prior chemotherapy, radiotherapy, or surgery for the premalignant lesions * No prior EGFR-targeted agents (e.g., cetuximab, gefitinib, or erlotinib)