A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of KRP-104 in Patients With Type 2 Diabetes Inadequately Controlled on Metformin Alone

Inclusion Criteria: 1. Age 18 to 70 years, inclusive; 2. Males and females of non-childbearing potential; 3. Diagnosis of type 2 diabetes mellitus according; and 4. On a stable dose of metformin monotherapy at randomization (can be on other oral therapies or naive at study entry Exclusion Criteria: 1. History of type 1 diabetes mellitus or history of diabetic ketoacidosis or persistent hypoglycemia; 2. History or presence of alcoholism or drug abuse 3. Typical consumption of ≥10 drinks of alcohol weekly; 4. Presence of any of the following conditions: * Significant renal impairment (glomerular filtration rate \<60 mL/min \[to be calculated by the central laboratory\]); * Diabetic retinopathy; * Diabetic gastroparesis; * Active liver disease (other than asymptomatic nonalcoholic fatty liver disease), cirrhosis, or symptomatic gallbladder disease; 5. Uncontrolled high blood pressure; 6. History or evidence of cardiovascular or pulmonary disease 7. Must meet other laboratory and Medical History clinical criteria. Please contact recruitment center for referrals