Extended Release Nifedipine Treatment as Maintenance Tocolysis to Prevent Preterm Delivery

The Baruch Padeh Medical Center, Poriya

Overview

To evaluate the treatment efficacy and safety usig extended release nifedipine, as maintenance therapy to pregnant women who were hospitalized and treated for preterm labor until 34 weeks' gestation. After the PTL will stop, we will randomize these women for the treatment group and the control (no treatment) group. The main outcome will be preterm delivery before 34 weeks' gestation. the secondary outcome will be the side effects of the medication and the newborn/mother health variables.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Preterm Labor

Interventions

Nifedipine extended releaseDRUG

Nifedipine extended release PO 30 mg X2/d until 34 weeks' gestation

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * pregnancy week 24-33 * Singleton pregnancy * After successful treatment to stop PTL Exclusion Criteria: * Contraindications for Nifedipine extended release treatment.

Data from ClinicalTrials.gov

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