Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

University of Zurich10 enrolled

Overview

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations. Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Ischemia/Reperfusion Injury

Interventions

Sevoflurane (Preconditioning)DRUG

Inhalation of sub-anesthetic doses of sevoflurane

Eligibility

Sex: MALEMin age: 25 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: male * Non-smoker * No asthma * NPO * Volunteer Exclusion criteria: * Female * Chronic medication * Asthma * Smoking

Locations (1)

University Hospital of Zurich

Zurich, Switzerland

RECRUITING

Outcomes

Primary Outcomes

marker expression on blood cells

Time frame: December 2008

Central Contacts

01 Studienregister MasterAdmins

CONTACT

+41 (0)44 255 11 11

Data from ClinicalTrials.gov

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