Study of CryoSpray Ablation of Low Grade or High Grade Dysplasia Within Barrett's Esophagus

Inclusion Criteria: * Karnofsky performance status of 50-100% * Life expectancy greater than 5 years * Hematopoietic, Hepatic and Renal lab clearance * Previous endoscopy with histological confirmation of LGD or HGD within BE * For Group 2, deemed inoperable based on the following criteria: co-morbid conditions such as severe heart, lung, kidney or liver disease; or refusal of surgical intervention after a thorough unbiased discussion of surgery. * For Group 2, endoscopic ultrasound (EUS) evaluation demonstrating no evidence of invasion or metastatic lymph node involvement (T0N0M0 by EUS). Exclusion Criteria: * Pregnant, not practicing adequate contraception, intending to become pregnant, or lactating at any time during the study (approximately 2 years). * Esophageal stricture preventing passage of endoscope or catheter. * Active esophagitis * EMR performed less than 8 weeks prior to CSA treatment. * EMR performed on greater than 90% circumference of any area of the esophagus. * Any previous esophageal surgery, except fundoplication without complications. * Known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines. * Concurrent enrollment in an investigational drug or device trial that clinically interferes with the LCS Dysplasia endpoints. * Psychiatric or other illness deemed by the investigator as an inability to comply with this protocol. * Medically unfit or other contraindication to tolerate upper endoscopy. * Inability to tolerate therapy with a proton pump inhibitor (PPI). * Refusal or inability to give consent. * Other active malignancy (except nonmelanoma skin cancer or another cancer for which patient is deemed disease-free). * Concurrent chemotherapy. * Prior radiation therapy which involved the esophagus. * Prior adenocarcinoma involving the esophagus or stomach. * Prior or concurrent ablation therapy including, but not limited to, photodynamic therapy, multipolar electro coagulation, argon plasma coagulation, laser treatment, radio frequency, etc.