Prone Position for Non-intubated Patients With Acute Respiratory Failure

Karolinska University Hospital24 enrolled

Overview

The study will test the hypothesis that the prone position can be used to reduce the need for intubation and mechanical ventilation in patients with acute respiratory failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Respiratory Failure

Interventions

Prone positionOTHER

Prone position during spontaneous breathing.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * bilateral pulmonary infiltrates or unilateral infiltrates involving more than one lobe on CXR * PaO2/FIO2 \< 40 kPa * RR \> 25, or attending intensivist considering likelihood of intubation \> 50% Exclusion Criteria: * unsuited for the prone position * fulfilled inclusion criteria for more than 5 days (120 h) * immunosuppression * chronic lung disease * decision of withdrawal or limitation of therapy * pulmonary infiltrates of cardiac origin * decreased GCS level * PaCO2 \> 10 * attending intensivist considering the patient unsuited for the prone position * BMI \> 33

Locations (1)

Karolinska University Hospital Solna

Stockholm, Sweden

RECRUITING

Outcomes

Primary Outcomes

Need for intubation and mechanical ventilation

Time frame: Duration of hospital stay

Central Contacts

Johan Petersson, MD

CONTACT

+4685172066 johan.petersson@karolinska.se

Data from ClinicalTrials.gov

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