Face Reconstruction by Allotransplantation of Composite Tissues

Inclusion Criteria: * Age 18 through 65 years * Signed written informed consent * patient with a loss of substance of the median third of the face by traumatisms or not carrying the totality of the lips with or without the nasal pyramid. * validation of the feasibility by a committee of expert in plastic surgery and maxillofacial * patient with a positive psychologic evaluation * patient with an anatomical evaluation and assessment pretransplantation positive normal infectious assessment * Good compliance and capacity of adaptation to the assessment difficulties * Patient with renal, hepatic, hematologic ,cardiac normal * Patient profiting from a Social Security cover * Patient informed patient, having signed a free assent lit with inclusion in the study Exclusion Criteria: * patient minor under supervision or deprived of freedom by court order or administrative. * person remaining in a medical or social establishment * pregnant. or breast-feeding women * patient presenting a sever cardiac pathology having a risk of decompensation into pre, per and post operational * patient presenting a hepatic pathology * Any cancer that has been in complete remission for \> 5 years malignancies tumoral lesion of the face with 2 years deadline of remission respected renal insufficiency chronic clearance of creatin \< 60l ml/mn * chronic respiratory insufficiency * patient presenting an active infection which can be worsened by the immunosuppression * patient presenting an active infection which can be worsened by the corticoid * patient with affection being able to compromise post-operative survival * patient with digestive ulcer * No known HIV infection * serology hepatitis B with circulating DNA highlighted quantitatively * personality emotional unstable * schizophrenic or not schizophrenic psychosis